Avanafil (Stendra)
Generic Avanafil is a new drug indicated for the treatment of erectile dysfunction in adult men. Physical stimulation is required for Generic Avanafil to be effective.
Avanafil is available in 3 strengths: 50 mg, 100 mg, and 200 mg.
About Avanafil
Generic Avanafil consists of a new active ingredient, It, a reversible, highly selective and potent phosphodiesterase type 5 (PDE5) inhibitor specific for cyclic guanosine monophosphate (cGMP).
When physical stimulation produces the local release of nitric oxide, inhibition of PDE5 by avanafil results in an improvement in cGMP in the corpora cavernosa of the penis, this occurs in the slackening of the smooth muscles and an influx of blood into the penile tissues, creating an erection.
It does not affect in the absence of physical stimulation.
Efficacy and clinical safety data
It was estimated in three , double-blind controlled versus placebo, randomized, conducted in parallel groups for up to 3 months, in the general population of patients with erectile dysfunction (ED), in patients with type 1 or type 2 diabetes and ED, as well as in patients with ED following bilateral radical prostatectomy with nerve maintenance.
A total of 1168 patients received it, which was taken as needed at 50 mg, 100 mg, and 200 mg doses. Patients were asked to take a dose of the study drug about 30 minutes before the onset of sexual activity.
In addition, a subgroup of patients was included in an open-label extension study in which 493 patients received it for at least six months and 153 patients for at least 12 months.
Patients initially received a 100 mg dose of avanafil and could, at any time in the study, have their it dose increased to 200 mg or decreased to 50 mg based on their individual response to treatment.
In all studies, there was a statistically significant improvement for all of the primary efficacy evaluation endpoints for the three doses of avanafil compared with the place.
These varieties were sustained during long-term treatment.
For all of the pivotal studies carried with it, the percentage of successful sexual attempts was significantly higher for all it doses compared to placebo, for efforts at all time intervals studied after taking the product.
